Penicillins can cause … 2006;5(5):467-8. This drug class causes decreased lacrimation, which may induce dry eye complaints. Some people begin to experience dry eye after laser vision correction surgery. 1. Hormone replacement therapy (HRT) with estrogens alone or in combination with progestins is a commonly prescribed therapy for post-menopausal women. Cholesterol -lowering drugs. Optom Mgmt. www.optometric.com/article.aspx?article=70708, Delay of Final Contact Lens Rule Requested by Congress, Conventional, Accelerated CXL Both Effective in Children, Diagnostic Tool Aids Refractive Assessment, Ray Tracing Offers Customizable LASIK Approach, Making the Diagnosis with the TFOS DEWS II. This can cause eye strain and dry eye, which may feel worse in the evening after a long day of work. For example, dry eyes may occur if you don't produce enough tears or if you produce poor-quality tears.Dry eyes feel uncomfortable. Fatty acids. This has a serious impact on quality of life and explains why some people may be dissatisfied with the outcome of their LASIK surgery. Dry Eye Culprits of the Drug World. While these drug categories are the most common offenders in producing dry eye problems, exceptions exist in every drug category. 18. Hypertensive Agents Acupuncture. Dry eye in post-menopausal women using hormone replacement therapy. Boston: Butterworth-Heinemann, 1995:957- 1006. Antidepressant & Parkinson’s Medications Any prescription medication with a nerve-inhibiting quality has the potential to cause dry eye symptoms. Certain classes of drugs are known to cause eye problems. Drug-Induced Ocular Side Effects. Institute of Medicine, National Academies. If you have found a solution, please share your success story with others. In some people the immune system attacks the tear glands just as it destroys other body tissue. These are available as supplements and in foods such as flaxseed, salmon and sardines. When selecting reference resources, choose those that are complete and updated frequently. Beta-blockers. Encephale. Brand name examples include Zoloft, Paxil, Elavil, Endep and Sinequan. 7. Bowling is in private group practice in Tuscaloosa, Ala. If a medication contributed to your symptoms, we would like to learn about that as well. Rev Optom. Joe Graedon is a pharmacologist who has dedicated his career to making drug information understandable to consumers. Phenothiazines are prescribed to manage schizophrenia. “These drugs can also cause central serous retinopathy, which is a collection of fluid in the macula in the back of the eye, and they can cause subconjunctival hemorrhages,” he says. In: GCY Chiou, ed. Gastrointestinal Medications Symptoms of blurred vision, cycloplegia and dry eye are transient and reversible.7. Birth control pills. 1992;2(4):73-96. J Am Optom Assoc. Fraunfelder FT, Fraunfelder FW, Edwards R. Ocular side effects possibly associated with isotretinoin usage. Rennie IG. 6. 3. Preventing Medication Errors: Quality Chasm Series. A great deal of information is available about hormone replacement therapy in post-menopausal women. In 2006, Long Island University awarded him an honorary doctorate as “one of the country's leading drug experts for the consumer.”, Eye drop preservative (benzalkonium chloride). high blood pressure medication, such as diuretics and beta-blockers The newer, more site-specific (H1 selective) antihistamines like Zyrtec (cetirizine, McNeil Consumer), Clarinex (desloratadine, Merck) and Allegra (fexofenadine, Sanofi-Adventis) are less likely to cause ocular dryness, but they may affect the tear film. Ophthalmic Toxicology. At the end of the day, it is our responsibility to make sure that our patients know how their systemic medications could be contributing to their ocular surface disease. 1981;52(3):257-8. JAMA. 17. Treatment will be different for each person depending on the root cause of the dry eye. 2. That may be because it doesn’t seem like such a big deal, especially compared to serious side effects like liver or kidney damage, heart attack or stroke. Antihistamines. Further study is needed, but some alternative medicine approaches may help relieve your dry eye symptoms. As eye care providers, we can be valuable in detecting ocular side effects of systemic medications, advising our patients and communicating with other members of our patients’ healthcare teams. Clinically important ocular reactions to systemic drug therapy. Optom Mgmt. Antihistamines are combined with anticholinergics in many OTC medications, such as cold preparations, sedatives, antidiarrheals and nasal decongestants.8 These combination medications induce dry eye, along with the commonly known effects of anticholinergics, which include mydriasis and decreased papillary response to bright light.8, Hormones This medication class includes the proton pump inhibitors: Prevacid (lansoprazole, Takeda), Prilosec (omeprazole, Procter & Gamble), Nexium (esomeprazole magnesium, AstraZeneca), Zantac (ranitidine, GlaxoSmithKline) and Tagamet (cimetidine, GlaxoSmithKline). The exact cause-and-effect relationship is unknown, but may be associated with a decreased aqueous component of the precorneal tear film.9. 2007 Apr;5(2):75-92. Isotretinoin (13-cis-retinoic acid) is a form of vitamin A that reduces the amount of oil released by oil glands in the skin.15 Vitamin A and its synthetic derivatives are collectively known as retinoids and are used to treat severe recalcitrant nodular acne, acne vulgaris and severe recalcitrant psoriasis, and to induce remission of leukemia.16 Isoretinoin has been shown to be secreted in tears by the lacrimal gland and has been associated with causing meibomian gland dysfunction—producing dry eye complaints, contact lens discomfort, blepharoconjunctivitis, transient blurring of vision and acute, transient refractive changes––especially myopic shifts.17 This synthetic medication affects the overproduction of skin lipids. This report, based on observations on 25,000 post-menopausal women, showed evidence of a significant increased risk of dry eye syndrome and severity of dry eye symptoms in women taking estrogen. Ocular side effects of selected systemic drugs. The effect of treatment and its related side effects in patients with severe ocular cicatricial pemphigoid. A major drug in this class is Cytoxan (cyclophosphamide, Bristol-Myers Squibb), which is also used to treat ocular cicatricial pemphigoid and primary Sjögren syndrome. Tricyclic antidepressants—Elavil (amitriptyline, Merck), Endep (amitriptyline, Roche), Adapin (doxepin, Lotus Biochemical), Sinequan (doxepin, Pfizer)—produce many anticholinergic side effects.12 These medications are being prescribed to a broader and younger population than in the past, which means there is an increased likelihood that your patients will display dry eye side effects. H2 receptor antagonists, like all antihistamines, can cause dry eye symptoms. List of drugs associated with a side effect named as Blurred Vision and related drug information. Lissamine green staining of conjunctiva and cornea in dry eye. Identify the ocular side effects of systemic medications. Xiidra® (lifitegrast ophthalmic solution 5%) became FDA … Decreased meibomian gland function also impacts the production of the lipid layer of the precorneal tear film, leading to tear film instability and enhanced surface evaporation, which results in dry eye syndrome. 2008 Jan;145(1):60-73. D ry eye is a multi-factoral disease of the tears and ocular surface; one such factor is the patient’s use of systemic medications.1 Many common systemic medications can affect ocular tissues, and medications that contribute to dry eye symptoms are present in many categories of commonly prescribed and over-the-counter (OTC) medications. There are various ways that medications contribute to dry eye syndrome. Pharmaceuticals that can cause dry eye symptoms include certain medications used to treat hypertension such as central-acting agents and diuretics; antihistamines and decongestants, in concert with anticholinergics; hormones; certain antidepressants; pain relievers, such as ibuprofen and lortab; and dermatologic agents. Physicians and pharmacists rarely mention dry eyes as a drug side effect. Because this risk has been shown to increase with longer durations of estrogen use, patients on HRT with estrogens should be monitored for dry eye problems.11, Antidepressants … Popular medicines like Zoloft (sertraline) and Paxil (paroxetine) belong to a different class of antidepressants, called selective serotonin reuptake inhibitors (SSRIs). As always, the best course is to educate our patients about the role their medications play in their dry eye complaints. “Many doctors think erectile dysfunction drugs cause … Debra A. Schaumberg, Sc.D., O.D., M.P.H., and colleagues reported a 69% increase in dry eye symptoms in women who were taking estrogen compared to the control group.10 Additionally, the study reported that women who were taking a progesterone or progesterone combination also experienced a 29% increase in dry eye symptoms over women not on HRT. Medication without first list of medications that cause dry eyes with the outcome of their LASIK surgery the cause of the drug still! And misery h2 receptor antagonists, like all antihistamines, antidepressants,,! Are complete and updated frequently eds. ), Sobaci E, et al system... And dose dependent.20 contraceptive agents is commonly implicated in dry eye complaints medications! With this information does not appear in their dry eye complaints, although this does. Help us with this information does not appear in their individual package inserts we would like learn... 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